2000 Ije 058-063
نویسندگان
چکیده
tality in industrialized societies. However, a significant part of the variation of the incidence of atherosclerosis diseases is not explained by its recognized risk factors. To enhance understanding of and to be able to prevent the atherosclerotic process, additional risk markers need to be identified. Sialic acid comprises a family of acylated derivates of neuraminic acid. It is widely distributed in mammals, usually occurring as a terminal component at the nonreducing end of carbohydrate chains of glycoproteins and glycolipids. The concentration of serum total sialic acid (S-TSA) is one recently investigated risk marker for cardiovascular mortality and atherosclerosis. In both men and women, coronary heart disease (CHD) and stroke mortality are about twofold higher in the highest 25% of the S-TSA distribution compared to the lowest 25%.1,2 There is also a positive association between the S-TSA concentration and carotid artery atherosclerosis measured by B mode ultrasound.3 Furthermore, in a recent prospective study, angiographically defined change in coronary atherosclerosis correlated 1 1 1 1 2 3 4 5 6 7 8 9 1 0 1 1 1 1 1 2 1 3 1 4 1 5 1 6 1 7 1 8 1 9 2 0 1 1 2 1 2 2 2 3 2 4 2 5 2 6 2 7 2 8 2 9 3 0 1 1 3 1 3 2 3 3 3 4 3 5 3 6 3 7 3 8 3 9 4 0 1 1 4 1 4 2 4 3 4 4 4 5 4 6 4 7 4 8 4 9 5 0 1 1 5 1 5 2 53
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